Mot-C
MOTS-c is a mitochondrial-derived peptide investigated for its role in optimizing metabolic function, increasing cellular energy (ATP), and improving insulin sensitivity. It acts as an exercise mimetic, with research suggesting it may promote fat oxidation, increase stamina, and reduce metabolic decline. It is researched in the context of supporting metabolic health and cellular resilience
Key benefits
Metabolic & Weight Management: MOTS-c treatment has been shown to prevent obesity and insulin resistance in mice fed a high-fat diet (HFD) by regulating the AMPK pathway, which enhances glucose uptake.
Physical Performance & Muscle Growth:Studies in mice show MOTS-c reduces myostatin, a protein that inhibits muscle growth, thus improving metabolic function and increasing muscle mass.
Aging & Longevity: In D-galactose-induced aging models,
dosages reduced cellular stress, protected against age-related decline in skin collagen and elastin, and lowered inflammation in various tissues.
Cardiovascular & Bone Health: MOTS-c has been shown to improve endothelial dysfunction and, when used in bone cancer pain (BCP) models, it inhibited osteoclast formation (bone destruction) at
Mechanism of Action: Unlike other mitochondrial peptides, MOTS-c operates by migrating to the nucleus and regulating genes responsible for metabolic homeostasis.
Medical journal Data
National library of medicine
https://pmc.ncbi.nlm.nih.gov/articles/PMC11532206/
Alzheimer discovery
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/MOTS-c.pdf
University of southern California (USC)
